解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We consider a capture-recapture model in which capture probabilities vary with time and with behavioral response. Two inference procedures are developed under the assumption that recapture probabilities bear a constant relationship to initial capture probabilities. These two procedures are the maximum likelihood metho...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2000.00427.x
更新日期:2000-06-01 00:00:00
abstract::Consider a collection of spatially clustered objects where the clusters are geographically rare. Of interest is estimation of the total number of objects on the site from a sample of plots of equal size. Under these spatial conditions, adaptive cluster sampling of plots is generally useful in improving efficiency in e...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2000.00503.x
更新日期:2000-06-01 00:00:00
abstract::We derive a likelihood score method for interval estimation of the intraclass version of the kappa coefficient of agreement with binary classification using a general theory of Bartlett (1953, Biometrika 40, 306-317). By exact evaluation, we investigate statistical properties of the score method, the chi-square goodne...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2000.00583.x
更新日期:2000-06-01 00:00:00
abstract::There is a simple robust variance estimator for cluster-correlated data. While this estimator is well known, it is poorly documented, and its wide range of applicability is often not understood. The estimator is widely used in sample survey research, but the results in the sample survey literature are not easily appli...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2000.00645.x
更新日期:2000-06-01 00:00:00
abstract::Phase I trials to study the pharmacokinetic properties of a new drug generally involve a restricted number of healthy volunteers. Because of the nature of the group involved in such studies, the appropriate distributional assumptions are not always obvious. These model assumptions include the actual distribution but a...
journal_title:Biometrics
pub_type: 临床试验,杂志文章
doi:10.1111/j.0006-341x.2000.00081.x
更新日期:2000-03-01 00:00:00
abstract::We introduce two test procedures for comparing two survival distributions on the basis of randomly right-censored data consisting of both paired and unpaired observations. Our procedures are based on generalizations of a pooled rank test statistic previously proposed for uncensored data. One generalization adapts the ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2000.00154.x
更新日期:2000-03-01 00:00:00
abstract::Some failure time data come from a population that consists of some subjects who are susceptible to and others who are nonsusceptible to the event of interest. The data typically have heavy censoring at the end of the follow-up period, and a standard survival analysis would not always be appropriate. In such situation...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2000.00227.x
更新日期:2000-03-01 00:00:00
abstract::A Bayesian multivariate adaptive regression spline fitting approach is used to model univariate and multivariate survival data with censoring. The possible models contain the proportional hazards model as a subclass and automatically detect departures from this. A reversible jump Markov chain Monte Carlo algorithm is ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.01071.x
更新日期:1999-12-01 00:00:00
abstract::We consider Bayesian inference and model selection for prevalence estimation using a longitudinal two-phase design in which subjects initially receive a low-cost screening test followed by an expensive diagnostic test conducted on several occasions. The change in the subject's diagnostic probability over time is descr...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.01145.x
更新日期:1999-12-01 00:00:00
abstract::Serial dilution assays are widely employed for estimating substance concentrations and minimum inhibitory concentrations. The Poisson-Bernoulli model for such assays is appropriate for count data but not for continuous measurements that are encountered in applications involving substance concentrations. This paper pre...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.01215.x
更新日期:1999-12-01 00:00:00
abstract::We consider the problem of estimating a population size from successive catches taken during a removal experiment and propose two estimating functions approaches, the traditional quasi-likelihood (TQL) approach for dependent observations and the conditional quasi-likelihood (CQL) approach using the conditional mean an...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.01263.x
更新日期:1999-12-01 00:00:00
abstract::A method purporting to provide optimal allocations in bioequivalence studies fails to do so on both statistical and practical grounds. Reasons as to why this is so are given. ...
journal_title:Biometrics
pub_type: 评论,杂志文章
doi:10.1111/j.0006-341x.1999.01314.x
更新日期:1999-12-01 00:00:00
abstract::The standard approach to inference for random effects meta-analysis relies on approximating the null distribution of a test statistic by a standard normal distribution. This approximation is asymptotic on k, the number of studies, and can be substantially in error in medical meta-analyses, which often have only a few ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00732.x
更新日期:1999-09-01 00:00:00
abstract::In multivariate failure time data analysis, a marginal regression modeling approach is often preferred to avoid assumptions on the dependence structure among correlated failure times. In this paper, a marginal mixed baseline hazards model is introduced. Estimating equations are proposed for the estimation of the margi...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00805.x
更新日期:1999-09-01 00:00:00
abstract::Currently, the design of group sequential clinical trials requires choosing among several distinct design categories, design scales, and strategies for determining stopping rules. This approach can limit the design selection process so that clinical issues are not fully addressed. This paper describes a family of desi...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00874.x
更新日期:1999-09-01 00:00:00
abstract::We develop locally D-optimal designs for nonlinear models when the variance of the response is a function of its mean. Using the two-parameter Michaelis-Menten model as an example, we show that the optimal design depends on both the type of heteroscedasticity and the magnitude of the variation. In addition, our result...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00925.x
更新日期:1999-09-01 00:00:00
abstract::The characteristics of deleterious genes have been of great interest in both theory and practice in genetics. Because of the complex genetic mechanism of these deleterious genes, most current studies try to estimate the overall magnitude of mortality effects on a population, which is characterized classically by the n...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00376.x
更新日期:1999-06-01 00:00:00
abstract::Studies using a series of increasing doses of a compound, including a zero dose control, are often conducted to study the effect of the compound on the response of interest. For a one-way design, Tukey et al. (1985, Biometrics 41, 295-301) suggested assessing trend by examining the slopes of regression lines under ari...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00460.x
更新日期:1999-06-01 00:00:00
abstract::Zhao and Tsiatis (1997) consider the problem of estimation of the distribution of the quality-adjusted lifetime when the chronological survival time is subject to right censoring. The quality-adjusted lifetime is typically defined as a weighted sum of the times spent in certain states up until death or some other fail...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00530.x
更新日期:1999-06-01 00:00:00
abstract::Unless the true association is very strong, simple large-sample confidence intervals for the odds ratio based on the delta method perform well even for small samples. Such intervals include the Woolf logit interval and the related Gart interval based on adding .5 before computing the log odds ratio estimate and its st...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00597.x
更新日期:1999-06-01 00:00:00
abstract::Jolliffe and Jolliffe (1997, Biometrics 53, 1136-1142) proposed various models for data from an experiment on memory in coal tits. This article describes an alternative model, which fits equally well and which may be simpler to interpret. ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00660.x
更新日期:1999-06-01 00:00:00
abstract::Diggle's tests of spatial randomness based on empirical distributions of interpoint distances can be performed with and without edge-effect correction. We present here numerical results illustrating that tests without the edge-effect correction proposed by Diggle (1979, Biometrics 35, 87-101) have a higher power for s...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00156.x
更新日期:1999-03-01 00:00:00
abstract::In binomial group testing, unlike one-at-a-time testing, the test unit consists of a group of individuals, and each group is declared to be defective or nondefective. A defective group is one that is presumed to include one or more defective (e.g., infected, positive) individuals and a nondefective group to contain on...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00231.x
更新日期:1999-03-01 00:00:00
abstract::Power and sample-size formulas for testing the homogeneity of relative risks using the score method are presented. The homogeneity score test (Gart, 1985, Biometrika 72, 673-677) is formally equivalent to the Pearson chi-square test, although they look different. Results of this paper may be useful in assessing the va...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00289.x
更新日期:1999-03-01 00:00:00
abstract::In this paper we propose a new class of statistics to test a simple hypothesis against a family of alternatives characterized by a mixture model. Unlike the likelihood ratio statistic, whose large sample distribution is still unknown in this situation, these new statistics have a simple asymptotic distribution to whic...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00065.x
更新日期:1999-03-01 00:00:00
abstract::Prentice and Sheppard (1995, Biometrika 82, 113-125) proposed a method for estimating relative risks associated with poorly measured exposures using disease rates from multiple populations and exposure and confounding factor data from sample surveys of persons in each population. The method involved an assumption of i...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract::We propose a sequential approach for constructing multiple-objective locally optimal designs for nonlinear models. The technique used here is a general one and we demonstrate the added benefits of using a multiple-objective design over a single-objective design with examples from biomedical studies. ...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract::Some new scale estimators for the censored two-sample accelerated life model are introduced. They are zeros of some integrated weighted difference between the two cumulative hazard estimators. These estimators are asymptotically normal. The weight is chosen to result in estimators whose asymptotic variances do not inv...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::The validation of surrogate endpoints has been studied by Prentice (1989, Statistics in Medicine 8, 431-440) and Freedman, Graubard, and Schatzkin (1992, Statistics in Medicine 11, 167-178). We extended their proposals in the cases where the surrogate and the final endpoints are both binary or normally distributed. Le...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::We propose a generalized linear mixed model to estimate and test marginal effects on titers repeatedly measured by serial dilution assays. The link is log-log and the titer is assumed to follow a gamma distribution. The parameters are estimated by generalized estimating equations. The marginal effects are tested by me...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::This paper discusses interval estimation of the risk ratio (RR) between a secondary infection, given a primary infection, and the primary infection. Three asymptotic closed-form interval estimators are developed using Wald's test statistic, the logarithmic transformation, and Fieller's theorem. The performance of thes...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::Mixed longitudinal growth data consists of several observations on a characteristic over a limited age range for each individual in a study. This data is then combined to model growth over the total age range of all individuals in the study. The limited data collected on each individual precludes a subject-specific ap...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::In many medical experiments, data are collected across time, over a number of similar trials, or over a number of experimental units. As is the case of neuron spike train studies, these data may be in the form of counts of events per unit of time. These counts may be correlated within each trial. It is often of intere...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::We propose a design strategy for single-arm clinical trials in which the goals are to find a dose of an experimental treatment satisfying both safety and efficacy requirements, treat a sufficiently large number of patients to estimate the rates of these events at the selected dose with a given reliability, and stop th...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::The method based on the Kolmogorov backward equations of Little (1995, Biometrics 51, 1278-1291) for computing hazard functions for the multistage carcinogenesis models fails when model parameters are time-dependent. In addition to suggesting an alternative method based on the Kolmogorov forward equation, this note hi...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::I discuss diagnostic methods for discriminant analysis. The equivalence with linear regression is noted and regression diagnostics are considered. The leverage is a function of the linear discriminant function and the Mahalanobis distance of the observation from the group mean. The distribution of this distance is app...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::This paper presents an approach to handling missing covariates in the generalized estimating equation (GEE) model for binary outcomes when the probability of missingness depends on the observed outcomes and covariates. The proposed method is to replace the missing quantities in the estimating function with consistent ...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::Life-table methodology for interval-censored survival times is used to estimate marginal survival probabilities from data consisting of independent cohorts of correlated responses. We restrict our attention to situations where response times within cohorts are exchangeable and the marginal survival distributions are t...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::A common measure in clinical trials and epidemiologic studies is the number of events such as seizures, hospitalizations, or bouts of disease. Frequently, a binary measure of severity for each event is available but is not incorporated in the analysis. This paper proposes methodology for jointly modeling the number of...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::Ranked set sampling (RSS) utilizes inexpensive auxiliary information about the ranking of the units in a sample to provide a more precise estimator of the population mean of the variable of interest Y, which is either difficult or expensive to measure. However, the ranking may not be perfect in most situations. In thi...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00